Temporal study of wastewater surveillance from September 2020 to March 2021: an estimation of COVID-19 patients in Lahore, Pakistan.

The first aim of study was to quantify the viral load in the wastewater samples by RT-qPCR testing in Lahore population to estimate the number of patients affected and predict the next resurgence of COVID-19 wave in the city. The second aim of the study was to determine the hotspot areas of Lahore which remained positive more often for virus with high viral load. In this study, n = 420 sewage samples were collected on an average of two weeks intervals from 30 different sewage water disposal stations (14 sampling events) from Sept 2020 to March 2021. RNA was extracted and quantified by RT-qPCR without concentrating the virus in samples. Number of positive disposal sites (7-93%), viral load from sewage samples (100.296 to 103.034), and estimated patients (660-17,030) ranged from low to high according to the surge and restrain of 2nd and 3rd COVID-19 waves in the country. The viral load and estimated patients were reported high in January 2021 and March 2021 which were similar to the peak of 2nd and 3rd waves in Pakistan. Site 18 (Niaz Baig village DS) showed the highest viral load among all sites. Findings of the present study helped to estimate the number of patients and track the resurgence in COVID-19 waves in Lahore particularly, and in Punjab generally. Furthermore, it emphasizes the role of wastewater-based epidemiology to help policymakers strengthen the quarantine measures along with immunization to overcome enteric viral diseases. Local and national stake holders should work in collaboration to improve the environmental hygiene to control the disease.

Mental well-being during COVID-19 pandemic: the role of fear, social isolation and psychological resilience

Emergence of any pandemic raises serious concerns toward the psychological well-being of an individual and overall society. Although, the magnitude and intensity of the novelwellb coronavirus (COVID-19) pandemic are not precisely known yet, however, this pandemic has predominantly reshaped the global scenario. Scholars have begun to unfold the reality of this traumatic situation, but empirical research that focuses on the identification of key factors that could have a notable impact on mental wellbeing of the general population is limited. To fill this gap, this research endeavors to analyze the impact of fear of getting infected and social isolation on mental well-being during the pandemic. In addition, psychological resilience is used as a moderator between social isolation and mental well-being. A total of 714 responses were received through an online survey from university students across all provinces of Pakistan. The findings demonstrate that people who fear of being infected tend to engage in social isolation, and social isolation brings negative repercussions toward mental well-being. Interestingly, the study findings reveal that psychological resilience could mitigate the negative impact of social isolation on mental well-being. This study calls for creating and promoting awareness concerning psychological resilience in order to cope with the psychological challenges during this COVID-19 pandemic. (PsycInfo Database Record (c) 2023 APA, all rights reserved)

Renessans Helps in Early Clearance of SARS-CoV-2: In-Vivo Activity of the Iodine Complex in Rhesus macaque.

Iodine complexes have known antimicrobial properties along with reported in-vitro antiviral activity for several viruses. Renessans is one such product with iodine complexes and ascorbic acid. The present study was designed to determine its efficacy for SARS-CoV-2 in Rhesus macaque. Rhesus macaque were assigned to: A) prophylactic group (n = 3), (B) treatment group (n = 3), (C) infection control group (n = 4), and (D) negative control group (n = 4). Groups A, B, and C were challenged with 2 × 106 TCID of SARS-CoV-2. The prophylactic group (A) was administered Renessans from 5 days before infection till 8 days postinfection (DPI). The treatment group (B) was administered Renessans from 3 till 8 DPI. Group C was administered water-insoluble fractions only. Nasal swabs from all monkeys of groups A, B, and C remained positive for SARS-CoV-2 till 2 and 7 DPI, while the swabs became negative for groups A and B at 14 DPI. Likewise, fecal matter of monkeys in group A returned negative results during the experiment, while that of group B had significantly decreased viral load (101.5 genome copies/mL) compared to group C (103 genome copies/mL). Hence, it is concluded that Renessans has in-vivo SARS-CoV-2 activity and may result in early clearance of SARS-CoV-2.

Future Aspects of Digital Sustainability in Hotels: A Study on Digital Marketing Challenges with Proposed Solutions (Opportunities) during and Post COVID Era

Information and communication technology (ICT) advancement has created a plethora of opportunities for several business sectors, especially the industries that include star-classified Indian and international hotels. However, several business areas lack the required support system (digital challenges) for such areas as lack of education, training, and the capacity for building up of local people. Hoteliers promoting hotel rooms mimic home-based rooms are almost gone;it is just not feasible to keep up due to rapid changes in technology. It was observed that a hotel's tech cycle is much speedier than its refurbishment cycle. This research study was conducted in order to discuss the top 16 digital marketing challenges and their best possible solutions in the international hotel industry. The study's objective was to explore the digital sustainability for star-classified Indian and internationally classified hotels in the COVID-19 pandemic. The study was qualitative and explorative in nature.

Educational Blockchain: A Secure Degree Attestation and Verification Traceability Architecture for Higher Education Commission

Degree attestation verification and traceability are complex one-to-one processes between the Higher Education Commission (HEC) and universities. The procedure shifted to the digitalized manner, but still, on a certain note, manual authentication is required. In the initial process, the university verified the degree and stamp seal first. Then, a physical channel of degree submission to the receiving ends is activated. After that, the degree is attested while properly examining and analyzing the tamper records related to degree credentials through e-communication with the university for verification and validation. This issue poses a serious challenge to educational information integrity and privacy. Potentially, blockchain technology could become a standardized platform to perform tasks including issuing, verifying, auditing, and tracing immutable records, which would enable the HEC, universities, and Federal Education Ministry (FEM) to quickly and easily get attested and investigate the forge proof versions of certificates. Besides, decentralized distributed data blocks in chronological order provide high security between distributed ledgers, consensus engine, digital signature, smart contracts, permissioned application, and private network node transactions that guarantee degree record validation and traceability. This paper presents an architecture (HEDU-Ledger) and detail design of blockchain-enabled hyperledger fabric applications implementation for degree attestation verification and traceable direct channel design between HEC and universities. The hyperledger fabric endorses attestation records first, and then validates (committer) the degree and maintains the secure chain of tracing between stakeholder peer nodes. Furthermore, this HEDU-Ledger architecture avoids language and administrative barriers. It also provides robustness in terms of security and privacy of records and maintains integrity with secure preservation as compared to that of the other state-of-the-art methods.

A TWO-DECADE LITERATURE REVIEW ON CHALLENGES FACED BY SMES IN TECHNOLOGY ADOPTION

The purpose of this study is to discuss the importance of technology for SMEs. The world is moving towards technology 5.0, SMEs have not able to adopt technology 2.0 effectively. COVID-19 pandemic has taught the world about the importance of technology in effective working from remote places. In the first section of this study, the authors will discuss the importance of technology adoption;later, the second section will focus on the various challenges in the adoption of technology. The research methodology is based on a systematic literature review. The authors have reviewed the literature of the last twenty years to judge the challenges pertaining to technology adoption. The literature has been reviewed in a longitudinal manner. The findings of this study suggest that the significant challenges in technology adoption are the cost of technology and infrastructure, technical skills and efficiency, adoption challenges, lack of organizational support, and governmental support.

Aprendizaje en línea durante la pandemia de COVID-19: aplicación de la teoría de la autodeterminación en la "nueva normalidad"

Resumen La pandemia de COVID-19 ha introducido la noción de la “nueva normalidad” en la vida diaria al influir profundamente en la forma en que hemos vivido, estudiado y trabajado hasta su irrupción. Durante estos tiempos sin precedentes, la rápida transición del aprendizaje presencial tradicional al aprendizaje digital se observa como un cambio de paradigma en la educación superior. Inspirándose en el marco teórico de la autodeterminación, este estudio tiene como objetivo examinar el impacto del aprendizaje digital en la motivación de los estudiantes. También plantea la hipótesis del papel mediador, de las necesidades psicológicas básicas, en el nexo entre el aprendizaje digital y la motivación de los estudiantes. 689 estudiantes que han asistido a clases digitales en diez universidades (cinco públicas y cinco privadas) de Pakistán han respondido a la encuesta por Internet. Los resultados de esta investigación no confirman la relación directa entre el aprendizaje digital y la motivación de los estudiantes. Sin embargo, esta relación sí está mediatizada por las percepciones de los estudiantes sobre el grado en que sus necesidades psicológicas básicas han sido satisfechas / no satisfechas. Este estudio contribuye teórica y empíricamente a la literatura tanto de la psicología como de la educación superior, perteneciente al campo del aprendizaje digital que está en proceso de desarrollo. Las implicaciones prácticas de este estudio informan a los responsables de la formulación de políticas en el ámbito académico para que reflexionen sobre las necesidades psicológicas de los estudiantes dentro del entorno de la enseñanza virtual. The COVID-19 pandemic has introduced the notion of the “new normal” in daily life through profoundly influencing the way we used to live, study and work. During these unprecedented times, the rapid transition from traditional face-to-face learning to online learning has been viewed as a paradigm shift in higher education. Drawing impetus from the self-determination theoretical framework, the present study aims to examine the impact of the online learning climate on student’s engagement. It also hypothesizes the mediating role of basic psychological needs on the nexus between online learning and students’ engagement. Total 689 students taking online classes in ten (five publics and five private) universities of Pakistan responded to the web-based survey. The present study findings do not support the direct influence of the online learning climate on student engagement, nevertheless, this relationship was mediated by students’ perceptions concerning the extent to which their basic psychological needs were satisfied/ dissatisfied. This study theoretically and empirically contributes to both the psychology and higher education literature, pertaining to the developing field of online learning. The practical implications from this study inform policy-makers in academia to reflect on the students’ psychological needs within virtual teaching environment.

Online learning during the COVID-19 pandemic: Applying the self-determination theory in the ‘new normal’

The COVID-19 pandemic has introduced the notion of the “new normal” in daily life through profoundly influencing the way we used to live, study and work. During these unprecedented times, the rapid transition from traditional face-to-face learning to online learning has been viewed as a paradigm shift in higher education. Drawing impetus from the self-determination theoretical framework, the present study aims to examine the impact of the online learning climate on student’s engagement. It also hypothesizes the mediating role of basic psychological needs on the nexus between online learning and students’ engagement. Total 689 students taking online classes in ten (five publics and five private) universities of Pakistan responded to the web-based survey. The present study findings do not support the direct influence of the online learning climate on student engagement, nevertheless, this relationship was mediated by students’ perceptions concerning the extent to which their basic psychological needs were satisfied/ dissatisfied. This study theoretically and empirically contributes to both the psychology and higher education literature, pertaining to the developing field of online learning. The practical implications from this study inform policy-makers in academia to reflect on the students’ psychological needs within virtual teaching environment. Resumen La pandemia de COVID-19 ha introducido la noción de la “nueva normalidad” en la vida diaria al influir profundamente en la forma en que solíamos vivir, estudiar y trabajar. Durante estos tiempos sin precedentes, la rápida transición del aprendizaje presencial tradicional al aprendizaje digital se observa como un cambio de paradigma en la educación superior. Inspirándose en el marco teórico de la autodeterminación, este estudio tiene como objetivo examinar el impacto del aprendizaje digital en la motivación de los estudiantes. También plantea la hipótesis del papel mediador, de las necesidades psicológicas básicas, en el nexo entre el aprendizaje digital y la motivación de los estudiantes. 689 estudiantes que asistieron a clases digitales en diez universidades (cinco públicas y cinco privadas) de Pakistán respondieron a la encuesta preparada en la web. Los resultados de esta investigación no confirman la relación directa entre el aprendizaje digital y la motivación de los estudiantes, sin embargo, esta relación sí está mediatizada por las percepciones de los estudiantes sobre el grado en que sus necesidades psicológicas básicas estaban satisfechas / insatisfechas. Este estudio contribuye teórica y empíricamente a la literatura tanto de la psicología como de la educación superior, perteneciente al campo en desarrollo del aprendizaje digital. Las implicaciones prácticas de este estudio informan a los responsables de la formulación de políticas en el ámbito académico para que reflexionen sobre las necesidades psicológicas de los estudiantes dentro del entorno de la enseñanza virtual.